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Variation in basal heat shock protein 70 is correlated to core temperature in human subjects.

  • Lee Taylor
    ,
  • Marie E. Sandström
    ,
  • Leigh A. Madden
    ,
  • Jason C. Siegler
    ,
  • Ric J. Lovell
    ,
  • Adrian W. Midgley
  • University of Hull
Research Output: Contribution to journal Article Peer-review

Abstract

Heat shock proteins are highly conserved proteins and play an important chaperone role in aiding the folding of nascent proteins within cells. The heat shock protein response to various stressors, both in vitro and in vivo, is well characterised. However, basal levels of heat shock protein 70 (Hsp70) have not previously been investigated. Monocyte-expressed Hsp70 was determined every 4 h, over a 24 h time period, in 17 healthy male subjects (177 +/- 6.4 cm, 75.7 +/- 10.9 kg, 19.8 +/- 4.3 years) within a temperature and activity controlled environment. Core temperature was measured at 5-min intervals during the 24 h period. Hsp70 showed significant diurnal variation (F = 7.4; p < 0.001), demonstrating peaks at 0900 and 2100 hours, and a nadir at 05.00. Core temperature followed a similar temporal trend (range = 35.96-38.10 degrees C) and was significantly correlated with Hsp70 expression (r(s) = 0.44; p < 0.001). These findings suggest a high responsiveness of Hsp70 expression in monocytes to slight variations in core temperature.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 279-284

Journal (Volume, Issue Number)

Amino Acids (Volume 37, Issue 2)

Publication milestones

  • Published - 01/07/2009

Publication status

Published - 01/07/2009

ISSN

0939-4451

External Publication IDs

  • handle.net: 10547/295070
  • Scopus: 67650760547

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