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TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

  • Stefan D. Anker
    ,
  • Anna Baumgarten
    ,
  • Claudia Bang
    ,
  • Anika Tschirner
    ,
  • Anke Engelmann
    ,
  • Volker Adams
  • University of Bedfordshire
    ,
  • German Centre for Cardiovascular Research
    ,
  • Charité – Universitätsmedizin Berlin
    ,
  • Hannover Medical School
    ,
  • Fresenius AG
    ,
  • Deutsches Herzzentrum Berlin
Research Output: Contribution to journal Article Peer-review

Abstract

The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 1447-1452

Journal (Volume, Issue Number)

International Journal of Cardiology (Volume 168, Issue 2)

Publication milestones

  • Published - 30/09/2013

Publication status

Published - 30/09/2013

ISSN

0167-5273

External Publication IDs

  • handle.net: 10547/593473
  • Scopus: 84885330287

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