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Tropomyosin isoforms show unexpected differential effects on actin polymerization

Research Output: Contribution to journal Article Peer-review

Abstract

Tropomyosin is a rod-like coiled-coil protein that forms a continuous filament that is weakly associated, but firmly-attached to the surface of the actin filaments in all eukaryotic cells. Simple eukaryotes such as yeasts have only one or two different tropomyosin isoforms which are known to be essential and perform roles in regulating the actin cytoskeleton. However higher eukaryotes have larger numbers of tropomyosins, the number of which appear linked to organismal complexity. Mammals have 4 genes producing over 40 different isoforms by alternative splicing.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 562-563a

Journal (Volume, Issue Number)

Biophysical Journal (Volume 112, Issue SI3)

Publication milestones

  • Published - 03/02/2017

Publication status

Published - 03/02/2017

ISSN

0006-3495

External Publication IDs

  • handle.net: 10547/622843

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