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The triglyceride to high-density lipoprotein ratio identifies children who may be at risk of developing cardiometabolic disease

  • Daniel Bailey
    ,
  • Louise A. Savory
    ,
  • Sarah J. Denton
    ,
  • Ben Rhys Davies
    ,
  • Catherine J. Kerr
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Aim: It is important to develop simple, reliable methods to identify high-risk individuals who may benefit from intervention. This study investigated the association between the triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio and cardiometabolic risk, cardiorespiratory fitness and physical activity in children. Methods: Anthropometric, biochemical parameters, cardiorespiratory fitness and accelerometry determined physical activity were assessed in 155 children (80 girls) from 10 to 14 years of age from Bedfordshire, UK. Participants were grouped into high and low TG/HDL ratio groups, according to published thresholds. MANCOVA and logistic regression were used in the analysis. Results: Cardiometabolic risk factor levels were significantly higher in participants with a high TG/HDL ratio (p < 0.05). The odds of having high waist circumference (OR = 13.99; 95% CI 2.93, 69.25), elevated systolic blood pressure (5.27; 1.39, 20.01), high non-HDL cholesterol (19.47; 4.42, 85.81) and ≥2 cardiometabolic risk factors (15.32; 3.10, 75.79) were higher in participants with a high TG/HDL ratio. The TG/HDL ratio values were significantly lower in those with high cardiorespiratory fitness (p = 0.01), but there was no association with physical activity. Conclusion: These findings support the use of the TG/HDL ratio to identify children with cardiometabolic risk factors who may be at risk of developing cardiometabolic disease.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages e349

Journal (Volume, Issue Number)

Acta Paediatrica, International Journal of Paediatrics (Volume 03, Issue 8)

Publication milestones

  • Published - 01/08/2014

Publication status

Published - 01/08/2014

External Publication IDs

  • handle.net: 10547/582426
  • Scopus: 84905007044

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