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The effect of the hyperbaric environment on heat shock protein 72 expression in vivo

  • Lee Taylor
    ,
  • Adrian W. Midgley
    ,
  • Marie E. Sandström
    ,
  • Bryna Chrismas
    ,
  • Lars R. McNaughton
Research Output: Contribution to journal Article Peer-review

Abstract

Heat shock protein 72 (HSP72) is expressed in response to stress and has been demonstrated to follow a diurnal expression pattern within monocytes and is sensitive to changes in core temperature. Numerous studies have shown changes in HSP72 expression within cell lines exposed to hyperbaric conditions. No studies have investigated changes in HSP72 expression in vivo. Six males participated in the study and were exposed to hyperbaric air and hyperbaric oxygen a week apart. Monocyte HSP72 was analyzed by flow cytometry at 09:00, 13:00, 17:00, 21:00 with hyperbaric oxygen or hyperbaric air breathing commencing at 15:00 for 78 min at a pressure of 2.8 ATA. HSP72 under normoxia followed the established trend; however, following the hyperbaric air or oxygen exposure a reduction in detectable HSP72 was observed at 17:00 and 21:00. No changes in core temperature were observed between 13:00 and 21:00 for any condition. The data show that HSP72 expression is impaired following hyperbaric air (HA) exposure, when compared with control or hyperbaric oxygen (HO) exposure.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 142-153

Journal (Volume, Issue Number)

Research in Sports Medicine (Volume 20, Issue 2)

Publication milestones

  • Published - 01/04/2012

Publication status

Published - 01/04/2012

ISSN

1543-8627

External Publication IDs

  • handle.net: 10547/294911
  • Scopus: 84859451981

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