Skip to search boxSkip to navigationSkip to main content

Targeting peptides for microglia identified via phage display

  • Bushra Ahmed
    ,
  • Tatiana I. Samoylova
    ,
  • Vitaly Vodyanoy
    ,
  • Nancy E. Morrison
    ,
  • Alexandre M. Samoylov
    ,
  • Ludmila P. Globa
Research Output: Contribution to journal Article Peer-review

Abstract

Screening with a 7-mer phage display peptide library, a panel of cell-targeting peptides for the murine microglial cell line, EOC 20, was recognized. A number of similar, but not identical, sets of sequences representing more than 75% of all the cell line-binding clones were identified. Comparative analysis indicated that motif S/(T) F T/(X) Y W is present in the vast majority of the binding sequences. The selectivity and specificity of the dominant peptide sequence identified for microglia was confirmed using both phage displaying the peptide and the synthetic peptide alone.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 13-21

Journal (Volume, Issue Number)

Journal of Neuroimmunology (Volume 127, Issue 1-2)

Publication milestones

  • Published - 01/01/2002

Publication status

Published - 01/01/2002

ISSN

0165-5728

External Publication IDs

  • handle.net: 10547/302090
  • Scopus: 0036271136

Access to documents

Publication metrics