Targeting locoregional peritoneal dissemination in ovarian cancer

Adam Paige
,
Szymon Janczar
,
Janet S. Graham
,
Hani Gabra

Research Output: Contribution to journal Article Peer-review

Sustainable Development Goals

SDG 3 Good Health and Well

Abstract

Ovarian carcinoma is the most lethal of the gynecological malignancies. This cancer is characterized by a high frequency of peritoneal dissemination resulting in significant morbidity and mortality, a situation unlike many other cancers. Together with resistance to chemotherapy, this locoregional peritoneal dissemination appears to be the major challenge and obstacle to improving outcomes in ovarian cancer. Relatively little scientific effort has been invested in making significant progress in the latter; therefore, developing a sound understanding of the molecular events underlying that process would be helpful. The focus of this review is to discuss the research that has been undertaken preclinically and clinically to conceptually develop the principles of, understand and target locoregional peritoneal dissemination in ovarian cancer.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 133-147

Journal (Volume, Issue Number)

Expert Review of Obstetrics and Gynecology (Volume 4, Issue 2)

Publication milestones

Published - 01/03/2009

Publication status

Published - 01/03/2009

ISSN

1747-4108

External Publication IDs

handle.net: 10547/229051
Scopus: 77951718578

Access to documents

10.1586/17474108.4.2.133

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