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Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy

  • Jinyun Liu
    ,
  • Yingmin Qu
    ,
  • Guoliang Wang
    ,
  • Xinyue Wang
    ,
  • Wenxiao Zhang
    ,
  • Jingmei Li
  • Changchun University of Science and Technology
    ,
  • Jilin University
Research Output: Contribution to journal Article Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

This article studies the morphological and mechanical features of multinuclear and mononuclear SW480 colon cancer cells by atomic force microscopy to understand their drug‐resistance. The SW480 cells were incubated with the fullerenol concentrations of 1 mg/ml and 2 mg/ml. Morphological and mechanical features including the height, length, width, roughness, adhesion force and Young's modulus of three multinuclear cell groups and three mononuclear cell groups were imaged and analyzed. It was observed that the features of multinuclear cancer cells and mononuclear cancer cells were significantly different after the treatment with fullerenol. The experiment results indicated that the mononuclear SW480 cells were more sensitive to fullerenol than the multinuclear SW480 cells, and the multinuclear SW480 cells exhibited a stronger drug‐resistance than the mononuclear SW480 cells. This work provides a guideline for the treatments of multinuclear and mononuclear cancer cells with drugs.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 3-12

Journal (Volume, Issue Number)

Microscopy Research and Technique (Volume 81, Issue 1)

Publication milestones

  • Accepted/In press - 26/09/2017
  • Published - 09/10/2017

Publication status

Published - 09/10/2017

ISSN

1059-910X

External Publication IDs

  • handle.net: 10547/623560
  • Scopus: 85038091741

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