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Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

  • Stefan D. Anker
    ,
  • Sandra Palus
    ,
  • Stephan von Haehling
    ,
  • Valerie C. Flach
    ,
  • Anika Tschirner
    ,
  • Wolfram Doehner
  • University of Bedfordshire
    ,
  • Charité – Universitätsmedizin Berlin
    ,
  • German Centre for Cardiovascular Research
    ,
  • University of East Anglia
Research Output: Contribution to journal Article Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 3412-3418

Journal (Volume, Issue Number)

International Journal of Cardiology (Volume 168, Issue 4)

Publication milestones

  • Published - 09/10/2013

Publication status

Published - 09/10/2013

ISSN

0167-5273

External Publication IDs

  • handle.net: 10547/593469
  • Scopus: 84886306895

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