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Selective anticancer effect of Phellinus linteus on epidermoid cell lines studied by atomic force microscopy: anticancer activity on A431 cancer cells and low toxicity on HaCat normal cells

  • Zuobin Wang
    ,
  • Mingyan Gao
    ,
  • Yuxi Huang
    ,
  • Cuihua Hu
    ,
  • Jing Hu
    ,
  • Ying Wang
Research Output: Contribution to journal Article Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

The research on the morphological and mechanical properties of single cells has provided a crucial way of understanding the cellular physiology and metabolism. In this study, the selective anticancer effects of Phellinus linteus on A431 and HaCat cells and their morphological and mechanical properties were systematically investigated by atomic force microscopy (AFM). Notably, the cell morphology on the micronano scale was observed under both the physiological environment and immobilization conditions. The significant morphological changes of A431 cells from the flat to spherical shape, the increase of cell height, and the decrease of the particles on the cell membrane were confirmed to be related to the cell apoptosis under the treatment of the Phellinus linteus water extract (PLWE). Moreover, the small morphology variations of HaCat cells showed that the PLWE presented a high anticancer effect on A431 cells but low toxicity on HaCat cells, which indicated a potential cell selectivity between cancer and normal cells. This work proved that Phellinus linteus could be used as a potential candidate for selective anticancer treatments.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 4-16

Journal (Volume, Issue Number)

IEEE Nanotechnology Magazine (Volume 15, Issue 1)

Publication milestones

  • Accepted/In press - 10/11/2020
  • Published - 02/12/2020

Publication status

Published - 02/12/2020

ISSN

1932-4510

External Publication IDs

  • handle.net: 10547/624779
  • Scopus: 85097404994

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