Skip to search boxSkip to navigationSkip to main content

Response of bEnd.3 cells to growing behavior on the graphene oxide film with 2-D grating structure by two-beam laser interference

  • Jin Yan
    ,
  • Liang Cao
    ,
  • Lu Wang
    ,
  • Chengcheng Xie
    ,
  • Yan Liu
    ,
  • Zhengxun Song
  • Changchun University of Science and Technology
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Graphene (G) and its derivatives are important nanomaterials with potential medical applications for biosensors and implanting biomaterials. The hydrophobicity and surface microstructures of substrates have great influences on the biological and physical properties of the surface-bound cells. In this work, we used the two-beam laser interference (TBLI) technique to prepare a two-dimensional (2-D) grating structure on the surface of graphene oxide (GO) film. We investigated the effect of GO and the GO film with the 2-D grating structure substrates on the growth behavior of rat brain microvascular endothelial (bEnd.3) cells. The results demonstrated that the cell spreading area and the number of surface-bound cells were closely related to the hydrophobicity of the substrate and the presence of oxygen-containing functional groups (OCGs). Due to the interaction of laser and GO, the GO in the interference area was transformed into reduced graphene oxide (RGO). The grating-structured GO film significantly affected the direction of cell spreading and morphology. It has a good application prospect as a scaffold in tissue engineering, and promising applications in the fields that require highly directional growth of cells, such as nerve injury repair, tendon repair and regeneration.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 1141-1149 (9 pages)

Journal (Volume, Issue Number)

Applied Nanoscience (Switzerland) (Volume 11, Issue 4)

Publication milestones

  • Accepted/In press - 23/01/2021
  • Published - 22/02/2021

Publication status

Published - 22/02/2021

ISSN

2190-5509

External Publication IDs

  • handle.net: 10547/624891
  • Scopus: 85101703907

Access to documents

Publication metrics

Metrics

Download statistics
Download count
4