Skip to search boxSkip to navigationSkip to main content

Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives.

  • Lee Taylor
    ,
  • Rebecca V. Vince
    ,
  • Lars R. McNaughton
    ,
  • Adrian W. Midgley
    ,
  • Gerard Laden
    ,
  • Leigh A. Madden
Research Output:
Contribution to journal
Article
 Peer-review

Abstract

Microparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.

Publication Information

Output type

Research Output:
Contribution to journal
Article
 Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 507-513

Journal (Volume, Issue Number)

European Journal of Applied Physiology (Volume 105, Issue 4)

Publication milestones

  • Published - 01/03/2009

Publication status

Published - 01/03/2009

ISSN

1439-6319

Publication IDs

  • handle.net: 10547/295069
  • Scopus: 59449097235

Access to documents

Publication metrics