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Proteins and disease | Structural insight and functional diversity of mammalian fatty acid binding proteins in health and disease

  • Rutgers - The State University of New Jersey, New Brunswick
Research Output: Chapter in Book/Report/Conference proceeding Chapter Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

The mammalian Fatty Acid-Binding Protein (FABP) family consists of 9 members, each displaying a β barrel capped by 2 short α-helices. The FABPs exhibit distinct and overlapping tissue expression patterns and bind long chain fatty acids with high affinity. The FABPs use interactions with membranes and proteins to transport fatty acids to sites of utilization, and each FABP displays distinct tissue specific functions. Recently several FABPs have been shown to bind additional lipid ligands, notably endocannabinoids, and to exert systemic functions remote from their tissues of origin. Some FABPs are dysregulated in cancer and inflammatory diseases, offering potential as drug targets and biomarkers.

Publication Information

Output type

Research Output: Chapter in Book/Report/Conference proceeding Chapter Peer-review

Host publication Subtitle

Third Edition

Original language

English

Pages from-to (Number of pages)

Pages 63-76 (14 pages)

Publication milestones

  • Published - 02/08/2021

Publication status

Published - 02/08/2021

Edition

3rd

Volume

3

Publisher

Elsevier B.V., India, Australia, Germany, United States, China, Spain, Ireland, United Kingdom, Netherlands, Taiwan, Province of China, Brazil, France, Singapore

ISBN (Print)

9780128194607

ISBN (Electronic)

9780128220405

External Publication IDs

  • handle.net: 10547/625271
  • Scopus: 85118522986

Host publication title

Encyclopedia of Biological Chemistry

Host publication editors

  • Joseph Jez

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