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Preferential regulation of stably expressed genes in the human genome suggests a widespread expression buffering role of microRNAs

  • Zhen Yang
    ,
  • Dong Dong
    ,
  • Zhaolei Zhang
    ,
  • James Crabbe
    ,
  • Li Wang
    ,
  • Yang Zhong
  • Fudan University
    ,
  • East China Normal University
    ,
  • University of Toronto
    ,
  • Shanghai Center for Bioinformation Technology
    ,
  • Tibet University
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

In this study, we comprehensively explored the stably expressed genes (SE genes) and fluctuant genes (FL genes) in the human genome by a meta-analysis of large scale microarray data. We found that these genes have distinct function distributions. miRNA targets are shown to be significantly enriched in SE genes by using propensity analysis of miRNA regulation, supporting the hypothesis that miRNAs can buffer whole genome expression fluctuation. The expression-buffering effect of miRNA is independent of the target site number within the 3'-untranslated region. In addition, we found that gene expression fluctuation is positively correlated with the number of transcription factor binding sites in the promoter region, which suggests that coordination between transcription factors and miRNAs leads to balanced responses to external perturbations.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages S14

Journal (Volume, Issue Number)

BMC Genomics (Volume 13, Issue Suppl.7)

Publication milestones

  • Published - 01/01/2012

Publication status

Published - 01/01/2012

External Publication IDs

  • handle.net: 10547/293924
  • Scopus: 84878791690

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