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Novel retrotransposed imprinted locus identified at human 6p25

  • Randy Jirtle
    ,
  • Yue Zhang
    ,
  • Aiping Zhang
    ,
  • David A. Skaar
    ,
  • Yue Li
    ,
  • Dale Huang
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Differentially methylated regions (DMRs) are stable epigenetic features within or in proximity to imprinted genes. We used this feature to identify candidate human imprinted loci by quantitative DNA methylation analysis. We discovered a unique DMR at the 50-end of FAM50B at 6p25.2. We determined that sense transcripts originating from the FAM50B locus are expressed from the paternal allele in all human tissues investigated except for ovary, in which expression is biallelic. Furthermore, an antisense transcript, FAM50B-AS, was identified to be monoallelically expressed from the paternal allele in a variety of tissues. Comparative phylogenetic analysis showed that FAM50B orthologs are absent in chicken and platypus, but are present and biallelically expressed in opossum and mouse.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 5388-5400

Journal (Volume, Issue Number)

Nucleic Acids Research (Volume 39, Issue 13)

Publication milestones

  • Published - 01/01/2011

Publication status

Published - 01/01/2011

ISSN

0305-1048

External Publication IDs

  • handle.net: 10547/296168
  • Scopus: 79960804985

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