Multi-parameter AFM characterization of INS-1 cells

Fan Yang
,
Bowei Wang
,
Jiajia Wang
,
Yujuan Chen
,
Zuobin Wang

Changchun University of Science and Technology

Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Open access

Sustainable Development Goals

SDG 3 Good Health and Well

Abstract

AFM-based single cell force spectroscopy has been employed wildly, while more work is needed for the mechanical detection of diabetes-related cells (INS-1 cells). In this study, a multi-parameter AFM characterization was performed to detect the mechanical properties of INS-1 cells in situ. High resolution topographies and concurrent mechanics were obtained by taking the advantage of the quantitatively imaging (QI) mode AFM. The analyses of force curves and force maps jointly presented the multiple parameters involved in the cell mechanics. The AFM force spectroscopy measurement provides full analysis and comprehensive understanding of cell mechanics.

Publication Information

Output type

Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 152-155 (4 pages)

Publication milestones

Accepted/In press - 01/07/2021
Published - 17/11/2021

Publication status

Published - 17/11/2021

Publisher

Institute of Electrical and Electronics Engineers Inc., United States

Publication series

Publication series name: 2021 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2021 - Proceedings