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Light- induced electrode scanning microscopy

  • Fengyan Hou
    ,
  • Huanzhou Yang
    ,
  • Jianjun Dong
    ,
  • Xia Wang
    ,
  • Rui Wang
    ,
  • Tianzhu Yu
  • Changchun University of Science and Technology
    ,
  • Zhongshan Institute of Changchun University of Science and Technology
    ,
  • Aarhus University
Research Output: Contribution to journal Article Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Patch clamps and microelectrode arrays have been widely used to detect the electrical properties of cells in biomedicine. Yet, both technologies can record signals only in an invasive manner or at fixed positions. Based on the resolution (LAPS) and optically induced dielectrophoretic, we present a novel light-induced electrode scanning microscopy. It works like a “radar”, scans the whole area with living cells in culture, and detects the electrical signals of single cells on a photosensitive chip. In the system, a light pattern projected onto the chip is used to form the corresponding light-induced electrode, and the electrode scanning mode is implemented by moving the light pattern or the chip position for the measurement of the electrical characteristics of biological cells and cell localizations. It provides a new tool for the detection of cell electrical properties and is expected to become the next generation of electrophysiological detection technology.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 8747-8754 (8 pages)

Journal (Volume, Issue Number)

Analytical Chemistry (Volume 97, Issue 16)

Publication milestones

  • Accepted/In press - 05/04/2025
  • Published - 15/04/2025

Publication status

Published - 15/04/2025

ISSN

0003-2700

External Publication IDs

  • handle.net: 10547/626729
  • Scopus: 105004033631

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