Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells

Jochen Greiner
,
Lars Bullinger
,
Barbara Guinn
,
Hartmut Döhner
,
Michael Schmitt

Ulm University
,
King's College London

Research Output: Contribution to journal Article Peer-review

Abstract

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. With intensive induction therapy, most patients younger than 60 years achieve complete remission. However, even if these younger patients were treated intensively, more than 50% will relapse. Clinical results of patients older than 60 years are more unfavorable. Therefore, in all patients with AML, the overall survival is still low. In the past decade, several leukemia-associated antigens (LAA) have been identified in patients with acute myeloid leukemia. BAGE, BCL-2, OFA-iLRP, FLT3-ITD, G250, hTERT, PRAME, proteinase 3, RHAMM, survivin, and WT-1 are all LAAs that have been shown to induce CD8+ T-cell recognition and for some antigens also humoral immune responses. Interestingly, most of these LAAs are linked to cell cycle or proliferation. This article discusses the balance between LAA-driven leukemia cell expansion and the elimination of these cells through attacks on LAAs by the immune system. Current knowledge of the function and CD8+ T-cell recognition of LAAs is reviewed and an outlook is given on how to improve T-cell responses to LAAs in acute myeloid leukemia cells.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 7161-7166

Journal (Volume, Issue Number)

Clinical Cancer Research (Volume 14, Issue 22)

Publication milestones

Published - 15/11/2008

Publication status

Published - 15/11/2008

ISSN

1078-0432

External Publication IDs

handle.net: 10547/224578
Scopus: 58149359323

Access to documents

10.1158/1078-0432.CCR-08-1102

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