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Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation

  • Bushra Ahmed
    ,
  • Masaaki Tokuda
    ,
  • Yun-Fei Lu
    ,
  • Hideki Matsui
    ,
  • Osamu Miyamoto
    ,
  • Fuminori Yamaguchi
  • Kagawa University
    ,
  • Okayama University
Research Output: Contribution to journal Article Peer-review

Abstract

Multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) are thought to be involved in the induction of long-term potentiation (LTP). In the present study, LTP was induced by theta burst stimulation in the Schaffer collateral area of the stratum radiatum in the hippocampal CA1 region of the rat hippocampus. LTP-induced and control hippocampal slices were studied by Western blot and immunohistochemical analyses using CaMK-I, -II and -IV antibodies. Increased amounts of all three CaMKs were found in LTP-induced hippocampal slices as indicated by Western blot as well as by the density of their immunoreactivity. Our data clearly shows that not only CaMK-II but also CaMK-I and -IV contribute to synaptic plasticity formed in LTP.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 162-166

Journal (Volume, Issue Number)

Brain Research (Volume 755, Issue 1)

Publication milestones

  • Published - 01/01/1997

Publication status

Published - 01/01/1997

ISSN

0006-8993

External Publication IDs

  • handle.net: 10547/302093
  • Scopus: 0030894369

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