Intraarticular injection of allogenic chondroprogenitors for treatment of osteoarthritis in rabbit knee model

Osteoarthritis (OA) is the most common disabling degenerative joint disease in humans, characterized by breakdown of cartilage and compensatory overgrowth of bone.1 The prevalent strategies for management of OA include non-operative measures such as life style modification, use of anti-inflammatory drugs, intra-articular injection of lubricants as well as interventional therapies including lavage, debridement, marrow stimulation techniques, transplantation of grafts among others.2 The varied results with these modalities have prompted the search for other treatment options.