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Intermittent exercise with and without hypoxia improves insulin sensitivity in individuals with type 2 diabetes

  • Richard W. Mackenzie
    ,
  • Neil S. Maxwell
    ,
  • Paul Castle
    ,
  • B. Elliott
    ,
  • Gary Brickley
    ,
  • Peter Watt
  • University of Westminster
Research Output: Contribution to journal Article Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Context: Hypoxia and muscle contraction stimulate glucose transport activity in vitro. Exercise and hypoxia have additive effects on insulin sensitivity in type 2 diabetics (T2D). Objective: The objective of the study was to examine the effectiveness of intermittent exercise with and without hypoxia on acute- and moderate-term glucose kinetics and insulin sensitivity in T2D. Setting: The study was conducted at a university research center. Design, Participants, and Interventions: Eight male T2D patients completed the following: 1) 60 min of continuous exercise at 90% lactate threshold in hypoxia (HyEx60); 2) intermittent exercise at 120% lactate threshold, separated by periods of passive recovery (5:5 min) in hypoxia [Hy5:5; O2 ∼ 14.7 (0.2)%]; and 3) intermittent exercise (5:5 min) at 120% lactate threshold in normoxia (O2 ∼ 20.93%). Main Outcome Measures: Glucose appearance and glucose disappearance, using an adapted non-steady-state one-compartment model were measured. Homeostasis models of insulin resistance (HOMAIR), fasting insulin resistance index (FIRI), and β-cell function were calculated 24 and 48 h after exercise conditions. Results: Glucose disappearance increased from baseline (1.85 mg/kg · min−1) compared with 24 h (2.01 min/kg · min−1) after HyEx60 (P = 0.031). No difference was noted for both Hy5:5 (P = 0.064) and normoxia (P = 0.385). Hy5:5 demonstrated improvements in HOMAIR from baseline [d 1, 6.20 (0.40)] when comparisons were made with d 2 [4.83 (0.41)] (P = 0.0013). HOMAIR and FIRI improved in the 24 h (HOMAIR, P = 0.002; FIRI, P = 0.003), remaining reduced 48 h after HyEx60 (HOMAIR, P = 0.028; and FIRI, P = 0.034). Conclusion: HyEx60 offered the greatest improvements in acute and moderate-term glucose control in T2D. Intermittent exercise stimulated glucose disposal and improved post-exercise insulin resistance, which was enhanced when exercise was combined with hypoxia (Hy5:5). The data suggest a use of hypoxic exercise in treatment of T2D.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages E546-E555

Journal (Volume, Issue Number)

Journal of Clinical Endocrinology and Metabolism (Volume 97, Issue 4)

Publication milestones

  • Published - 01/04/2012

Publication status

Published - 01/04/2012

ISSN

0021-972X

External Publication IDs

  • handle.net: 10547/225584
  • Scopus: 84859555977

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