Increasing phytochemical-rich foods and Lactobacillus probiotics in men with low-risk prostate cancer: a randomised, double-blind, placebo-controlled trial

Robert J. Thomas
,
Stacey A. Kenfield
,
Madeleine Williams
,
Robert U. Newton
,
Jeffrey Aldous
,
Anita Mitra

Cambridge University Hospitals NHS Foundation Trust
,
Bedfordshire Hospitals NHS Foundation Trust
,
Addenbrooke’s Hospital
,
University of California at San Francisco
,
Edith Cowan University
,
University College London Hospitals NHS Foundation Trust

Research Output: Contribution to journal Article Peer-review

Open access

Sustainable Development Goals

SDG 3 Good Health and Well

Abstract

Men on active surveillance (AS), with prostate cancer, are very interested in dietary strategies that could improve their symptoms and help prevent progression of their disease. In this real-world trial involving 208 men, intake of phytochemical-rich food capsules helped slow prostate-specific antigen (PSA) progression significantly, and improved urinary symptoms and erectile function. What was novel about this study was that men randomised to take an additional blend of five Lactobacillus probiotics had a further three-fold slowing of PSA progression as well as reduction of inflammation. Currently, nearly 50% of men opt out of AS within 5 yr. If confirmed with further follow-up, these dietary interventions, alongside other lifestyle manoeuvres, could reassure men to remain on AS, and hence avoid the risks of radiotherapy, hormones, or surgery.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 193-198 (6 pages)

Journal (Volume, Issue Number)

European Urology Oncology (Volume 9, Issue 1)

Publication milestones

Accepted/In press - 06/10/2025
Published - 27/10/2025

Publication status

Published - 27/10/2025

External Publication IDs

handle.net: 10547/626975
Scopus: 105029550886
PubMed: 41152052

Access to documents

10.1016/j.euo.2025.10.003

final published version

Final published version, 623.82 KB

License:CC BY

https://euoncology.europeanurology.com/article/S2588-9311%2825%2900257-3/fulltext

Final published version

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