Skip to search boxSkip to navigationSkip to main content

Increased collagen synthesis rate during wound healing in muscle

  • Shaobo Zhou
    ,
  • Jonathan Salisbury
    ,
  • Victor R. Preedy
    ,
  • Peter W. Emery
  • King's College Hospital
    ,
  • King's College London
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Article number

e58324

Journal (Volume, Issue Number)

PLoS ONE (Volume 8, Issue 3)

Publication milestones

  • Published - 01/01/2013

Publication status

Published - 01/01/2013

External Publication IDs

  • handle.net: 10547/294842
  • Scopus: 84875107910

Access to documents

Publication metrics

Metrics

Download statistics
Download count
6