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IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

  • Diana C. Yánez
    ,
  • Hemant Sahni
    ,
  • Susan Ross
    ,
  • Anisha Solanki
    ,
  • Ching-In Lau
    ,
  • Eleftheria Papaioannou
  • University College London
    ,
  • Universidad San Francisco de Quito
    ,
  • Wellcome Trust
    ,
  • Cancer Research UK
    ,
  • University of Hamburg
    ,
  • Imperial College London
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 66-78

Journal (Volume, Issue Number)

European Journal of Immunology (Volume 49, Issue 1)

Publication milestones

  • Published - 26/10/2018

Publication status

Published - 26/10/2018

ISSN

0014-2980

External Publication IDs

  • handle.net: 10547/623197
  • Scopus: 85056360063

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