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Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

  • Diana C. Yánez
    ,
  • Ching-In Lau
    ,
  • Mira Manilal Chawda
    ,
  • Susan Ross
    ,
  • Anna Furmanski
    ,
  • Tessa Crompton
  • University College London
    ,
  • Universidad San Francisco de Quito
Research Output: Contribution to journal Article Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 1419-1423

Journal (Volume, Issue Number)

Journal of Allergy and Clinical Immunology (Volume 144, Issue 5)

Publication milestones

  • Published - 24/07/2019

Publication status

Published - 24/07/2019

ISSN

0091-6749

External Publication IDs

  • handle.net: 10547/623391
  • Scopus: 85070860628

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