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Gut hormone regulation and secretion via FFA1 and FFA4

  • Medical Research Council
Research Output: Chapter in Book/Report/Conference proceeding Chapter Peer-review

Abstract

The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatty acid receptors FFA1 and FFA4, which are highly expressed on enteroendocrine cells. These receptors are activated when free fatty acids (FFA) are absorbed across the intestinal epithelium, and provide a dynamic hormonal signal indicating that lipids are arriving in the bloodstream from the gut. This review addresses our current knowledge of how ingested triglycerides modulate gut hormone release via FFA1 and FFA4.

Publication Information

Output type

Research Output: Chapter in Book/Report/Conference proceeding Chapter Peer-review

Original language

English

Publication milestones

  • Published - 22/11/2016

Publication status

Published - 22/11/2016

Volume

236

Publisher

Springer, Japan, India, Australia, Germany, United States, United Arab Emirates, Austria, Switzerland, Italy, China, United Kingdom, Netherlands, Brazil, France, Singapore

Publication series

  • Publication series name: Handbook of Experimental Pharmacology
    Number: 236

External Publication IDs

  • handle.net: 10547/624681
  • Scopus: 85014069487

Host publication title

Free Fatty Acid Receptors

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