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Finger-prick autologous blood (FAB) eye drops for dry eye disease: single masked multi-dentre randomised controlled trial

  • Ali Hassan
    ,
  • Shafi Balal
    ,
  • Erica O'Mahony
    ,
  • Hakim-Moulay Dehbi
    ,
  • Shahina Pardhan
    ,
  • Rupert Richard Alexander Bourne
  • University College London
    ,
  • Moorfields Eye Hospital NHS Foundation Trust
    ,
  • Comprehensive Clinical Trials Unit
    ,
  • Anglia Ruskin University
    ,
  • Addenbrooke’s Hospital
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Purpose: To investigate the quantitative and qualitative efficacy of finger-prick autologous blood (FAB) eye drops versus conventional medical therapy for the treatment of severe dry eye disease (DED). Methods: Two centre, single masked, randomised controlled trial. Sixty patients in total were recruited with thirty patients (sixty eyes) treated with FAB eye drops four times per day in addition to their conventional DED treatment, and thirty patients (fifty-eight eyes) served as control subjects on conventional treatment alone. Ocular surface disease index (OSDI), Schirmer’s test, fluorescein ocular staining grade (OCSG) Oxford schema and fluorescein tear film break-up time (TBUT), were performed at baseline, at 4 and 8 weeks. Results: OSDI scores significantly decreased in the FAB arm by greater than −17.68 (−37.67 to −2.96, p=0.02) compared to the control arm. There were greater improvements in OCSG and TBUT in the FAB arm but these were non-significant (p>0.05). Conclusion: This feasibility study demonstrates adding FAB eye drops to conventional medical therapy for DED improves mean OSDI symptom score compared to conventional medical therapy alone. It may have particular use in settings where serum is unobtainable. An adequately powered and well-designed randomised trial is needed to further evaluate the long-term clinical benefit of FAB.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 3973-3979 (7 pages)

Journal (Volume, Issue Number)

Clinical Ophthalmology (Volume 16)

Publication milestones

  • Accepted/In press - 11/10/2022
  • Published - 02/12/2022

Publication status

Published - 02/12/2022

ISSN

1177-5467

External Publication IDs

  • handle.net: 10547/625595
  • Scopus: 85148939617
  • PubMed: 36483187
  • ORCID: /0000-0003-4369-8202/work/130583073

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