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Expression of calbindin-D28K by reactive astrocytes in gerbil hippocampus after ischaemia

  • Bushra Ahmed
    ,
  • Tetsuhiko Toyoshima
    ,
  • Shinichi Yamagami
    ,
  • Li Jin
    ,
  • Osamu Miyamoto
    ,
  • Toshifumi Itano
  • Kagawa University
Research Output: Contribution to journal Article Peer-review

Abstract

Calbindin-D28K (Calbindin) is a member of the superfamily of calcium-binding proteins that is implicated in the regulation of intracellular calcium. In the adult mammalian brain, calbindin was thought to be present only in neurones, where it is believed to serve a neuroprotective role. We now report the expression of calbindin after ischaemia in reactive astrocytes in the CA1 subfield of the hippocampus. Since other calcium-binding proteins, such as S-100 and calmodulin, which induce transformation or proliferation of glia, occur in astrocytes, it is conceivable that the expression of calbindin after ischaemia might be an important part of the process of gliosis.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 2087-2091

Journal (Volume, Issue Number)

NeuroReport (Volume 7, Issue 13)

Publication milestones

  • Published - 02/09/1996

Publication status

Published - 02/09/1996

ISSN

0959-4965

External Publication IDs

  • handle.net: 10547/294868
  • Scopus: 0029852604

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