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Evaluations of 5-fluorourcil treated lung cancer cells by atomic force microscopy

  • Xiaolin Jiang
    ,
  • Ke Ma
    ,
  • Cuihua Hu
    ,
  • Mingyan Gao
    ,
  • Jiashuo Zhang
    ,
  • Ying Wang
  • Changchun University of Science and Technology
Research Output: Contribution to journal Article Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Atomic force microscopy (AFM) can be used to obtain the physical information of single live cancer cells; however, the physical changes in live cells with time based on AFM remain to be studied, which play a key role in the evaluation of the efficacy and side effects of drugs. Herein, the treatment of the A549 cell line with the anticarcinogen 5-fluorouracil has been discussed based on the AFM analysis of their continuous physical changes, including their surface morphology, height, adhesion and Young's modulus, with time. In comparison, the African green monkey kidney (Vero) cell line was tested as normal cells to determine the side effects of 5-fluorouracil. The results show that the optimal concentration of 5-fluorouracil is about 500 μM, which presents the best anticancer effect and mild side effects.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 4977-4982

Journal (Volume, Issue Number)

Analytical Methods (Volume 11)

Publication milestones

  • Accepted/In press - 06/09/2019
  • Published - 06/09/2019

Publication status

Published - 06/09/2019

ISSN

1759-9660

External Publication IDs

  • handle.net: 10547/623554
  • Scopus: 85073591554

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