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Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro

  • Jing Hu
    ,
  • Jie Jiao
    ,
  • Ying Wang
    ,
  • Mingyan Gao
    ,
  • Zhengcheng Lu
    ,
  • Fan Yang
  • Changchun University of Science and Technology
    ,
  • University of Bedfordshire
Research Output: Contribution to journal Article Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Hepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Article number

102710

Journal (Volume, Issue Number)

Micron (Volume 124)

Publication milestones

  • Accepted/In press - 01/07/2019
  • Published - 02/07/2019

Publication status

Published - 02/07/2019

ISSN

0968-4328

External Publication IDs

  • handle.net: 10547/623556
  • Scopus: 85068259302
  • PubMed: 31280008

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