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Disinfection byproducts of haloacetaldehydes disrupt hepatic lipid metabolism and induce lipotoxicity in high-fat culture conditions

  • Lili Yang
    ,
  • Zhiqiang Jiang
    ,
  • Lan Yang
    ,
  • Weiwei Zheng
    ,
  • Yu Chen
    ,
  • Fei Qu
  • Fudan University
    ,
  • University of Oxford
    ,
  • ScitoVation LLC
    ,
  • Qingdao University
Research Output:
Contribution to journal
Article
 Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Unhealthy lifestyles, obesity, and environmental pollutants are strongly correlated with the development of nonalcoholic fatty liver disease (NAFLD). Haloacetaldehyde-associated disinfection byproducts (HAL-DBPs) at various multiples of concentrations found in finished drinking water together with high-fat (HF) were examined to gauge their mixed effects on hepatic lipid metabolism. Using new alternative methods (NAMs), studying effects in human cells in vitro for risk assessment, we investigated the combined effects of HF and HAL-DBPs on hepatic lipid metabolism and lipotoxicity in immortalized LO-2 human hepatocytes. Coexposure of HAL-DBPs at various multiples of environmental exposure levels with HF increased the levels of triglycerides, interfered with de novo lipogenesis, enhanced fatty acid oxidation, and inhibited the secretion of very low-density lipoproteins. Lipid accumulation caused by the coexposure of HAL-DBPs and HF also resulted in more severe lipotoxicity in these cells. Our results using an in vitro NAM-based method provide novel insights into metabolic reprogramming in hepatocytes due to coexposure of HF and HAL-DBPs and strongly suggest that the risk of NAFLD in sensitive populations due to HAL-DBPs and poor lifestyle deserves further investigation both with laboratory and epidemiological tools. We also discuss how results from our studies could be used in health risk assessments for HAL-DBPs.

Publication Information

Output type

Research Output:
Contribution to journal
Article
 Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 12356-12367 (12 pages)

Journal (Volume, Issue Number)

Environmental Science and Technology (Volume 58, Issue 28)

Publication milestones

  • Accepted/In press - 13/06/2024
  • Published - 02/07/2024

Publication status

Published - 02/07/2024

ISSN

0013-936X

Publication IDs

  • handle.net: 10547/626327
  • Scopus: 85197616533

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