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Direct imaging of IgE on the mica surface by tapping-mode atomic force microscopy

  • Jing Hu
    ,
  • Ying Wang
    ,
  • Mingyan Gao
    ,
  • Zhengxun Song
    ,
  • Yujuan Chen
    ,
  • Zuobin Wang
  • Changchun University of Science and Technology
Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Abstract

Immunoglobulin E (IgE) antibody is essential in the functioning of the immune system, so the study of IgE has its practical and profound significance. Herein, the effect of protein concentration and adsorption time on IgE morphology of mica surface was investigated. For this purpose, atomic force microscopy (AFM) has been performed for monitoring protein morphology at different concentrations and adsorption times. In addition, the height and average roughness of IgE were also obtained. The changes of IgE molecule morphology including the shape, height and average roughness indicated that the interactions of protein-surface and protein-protein were varying with the protein concentration and adsorption time.

Publication Information

Output type

Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Original language

English

Publication milestones

  • Published - 02/02/2020

Publication status

Published - 02/02/2020

Publisher

Institute of Electrical and Electronics Engineers Inc., United States

External Publication IDs

  • handle.net: 10547/624160
  • Scopus: 85078836381

Host publication title

2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)

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