Skip to search boxSkip to navigationSkip to main content

Cleavage of Mer Tyrosine Kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis

  • Ah-Lai Law
    ,
  • Célia Parinot
    ,
  • Jonathan Chatagnon
    ,
  • Basile Gravez
    ,
  • José Alain Sahel
    ,
  • Shomi S. Bhattacharya
  • Sorbonne Université
    ,
  • Institut national de la santé et de la recherche médicale
    ,
  • CNRS
    ,
  • University College London
    ,
  • Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER)
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 4941-4952

Journal (Volume, Issue Number)

Journal of Biological Chemistry (Volume 290, Issue 8)

Publication milestones

  • Published - 20/02/2015

Publication status

Published - 20/02/2015

ISSN

0021-9258

External Publication IDs

  • handle.net: 10547/624685
  • Scopus: 84929096320

Access to documents

Publication metrics

Metrics

Download statistics
Download count
17