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Chronic probiotic supplementation with or without glutamine does not influence the eHsp72 response to a multi-day ultra-endurance exercise event

  • Hannah Marshall
    ,
  • Bryna C. Chrismas
    ,
  • Craig Anthony Suckling
    ,
  • Justin D. Roberts
    ,
  • Josh Foster
    ,
  • Lee Taylor
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Probiotic and glutamine supplementation increases tissue Hsp72, but their influence on extracellular Hsp72 (eHsp72) has not been investigated. The aim of this study was to investigate the effect of chronic probiotic supplementation, with or without glutamine, on eHsp72 concentration before and after an ultramarathon. Thirty-two participants were split into 3 independent groups, where they ingested probiotic capsules (PRO; n = 11), probiotic + glutamine powder (PGLn; n = 10), or no supplementation (CON; n = 11), over a 12-week period prior to commencement of the Marathon des Sables (MDS). eHsp72 concentration in the plasma was measured at baseline, 7 days pre-race, 6-8 h post-race, and 7 days post-race. The MDS increased eHsp72 concentrations by 124% (F[1,3] = 22.716, p < 0.001), but there was no difference in the response between groups. Additionally, PRO or PGLn supplementation did not modify pre- or post-MDS eHsp72 concentrations compared with CON (p > 0.05). In conclusion, the MDS caused a substantial increase in eHsp72 concentration, indicating high levels of systemic stress. However, chronic PRO or PGLn supplementation did not affect eHsp72 compared with control pre- or post-MDS. Given the role of eHsp72 in immune activation, the commercially available supplements used in this study are unlikely to influence this cascade.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 876-883

Journal (Volume, Issue Number)

Applied Physiology, Nutrition and Metabolism (Volume 42, Issue 8)

Publication milestones

  • Accepted/In press - 17/04/2017
  • Published - 01/05/2017

Publication status

Published - 01/05/2017

ISSN

1715-5312

External Publication IDs

  • handle.net: 10547/625085
  • Scopus: 85026308319

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