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Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: Implications for the biosynthesis of ethyl-substituted juvenile hormones

  • Guy Grant
    ,
  • Michel Cusson
    ,
  • Catherine Béliveau
    ,
  • Stephanie E. Sen
    ,
  • Sophie Vandermoten
    ,
  • Robert G. Rutledge
Research Output: Contribution to journal Article Peer-review

Abstract

The sesquiterpenoid juvenile hormone (JH) regulates insect development and reproduction. Most insects produce only one chemical form of JH, but the Lepidoptera produce four derivatives featuring ethyl branches. The biogenesis of these JHs requires the synthesis of ethyl-substituted farnesyl diphosphate (FPP) by FPP synthase (FPPS). To determine if there exist more than one lepidopteran FPPS, and whether one FPPS homolog is better adapted for binding the bulkier ethyl-branched substrates/products, we cloned three lepidopteran FPPS cDNAs, two from Choristoneura fumiferana and one from Pseudaletia unipuncta. Amino acid sequence comparisons among these and other eukaryotic FPPSs led to the recognition of two lepidopteran FPPS types.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 742-758

Journal (Volume, Issue Number)

Proteins: Structure, Function and Genetics (Volume 65, Issue 3)

Publication milestones

  • Published - 01/01/2006

Publication status

Published - 01/01/2006

ISSN

0887-3585

External Publication IDs

  • handle.net: 10547/294529
  • Scopus: 33750055738

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