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Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.

  • University of Cambridge
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted from the upper small intestine, which plays an important physiological role in the control of glucose metabolism through its incretin action to enhance glucose-dependent insulin secretion. GIP has also been implicated in postprandial lipid homeostasis. GIP is secreted from enteroendocrine K-cells residing in the intestinal epithelium. K-cells sense a variety of components found in the gut lumen following food consumption, resulting in an increase in plasma GIP signal dependent on the nature and quantity of ingested nutrients. We review the evidence for an important role of sodium-coupled glucose uptake through SGLT1 for carbohydrate sensing, of free-fatty acid receptors FFAR1/FFAR4 and the monoacyl-glycerol sensing receptor GPR119 for lipid detection, of the calcium-sensing receptor CASR and GPR142 for protein sensing, and additional modulation by neurotransmitters such as somatostatin and galanin. These pathways have been identified through combinations of in vivo, in vitro and molecular approaches.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 170206

Journal (Volume, Issue Number)

Peptides (Volume 125)

Publication milestones

  • Accepted/In press - 14/11/2019
  • Published - 19/11/2019

Publication status

Published - 19/11/2019

ISSN

0196-9781

External Publication IDs

  • handle.net: 10547/623903
  • Scopus: 85075825111

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