Skip to search boxSkip to navigationSkip to main content

Calculation of protein domain structural similarity using two-dimensional representations

  • Guy Grant
    ,
  • Richard Allen
    ,
  • B.C.P. Allen
    ,
  • W. Graham Richards
  • University of Oxford
Research Output: Contribution to journal Article Peer-review

Abstract

By reducing protein structures to two-dimensional representations, it is possible to speed up the alignment of the structures and hence calculate similarity indices faster that using three-dimensional representations. Using amino acid based representations gives much better discrimination between proteins and faster calculations. Taking into account the relative similarity of the amino acids involved allowed improved accuracy at very little time cost.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 134-143

Journal (Volume, Issue Number)

Journal of Chemical Information and Modeling (Volume 43, Issue 1)

Publication milestones

  • Published - 01/01/2003

Publication status

Published - 01/01/2003

ISSN

1549-9596

External Publication IDs

  • handle.net: 10547/294683
  • Scopus: 0037208268

Access to documents

Publication metrics