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Bi-layered disulfiram-loaded fiber membranes with antibacterial properties for wound dressing

  • Chenchen Xie
    ,
  • Jin Yan
    ,
  • Siyuan Cao
    ,
  • Ri Liu
    ,
  • Baishun Sun
    ,
  • Ying Xie
  • Changchun University of Science and Technology
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

In this study, the bi-layered disulfiram-loaded fiber membranes with the antibacterial activity and different surface wettabilities are prepared using electrospinning technology. In the application of wound dressing, the hydrophilic surface of fiber membranes is beneficial for cell adhesion and drug release to heal the wound. Meanwhile, the outside hydrophobic surface is able to block water penetration to reduce the probability of wound infection. The obtained bi-layered drug-loaded fiber membranes are composed of polyvinylidene fluoride (PVDF) bottom surface and disulfiram (DSF)/polylactic acid (PLA) top surface. To modify the top surface wettability, the oxygen plasma modification of bi-layered membranes was carried out. The morphology, wettability, and chemical compositions of bi-layered drug-loaded fiber membranes were analyzed using the scanning electronic microscope (SEM), drop shape analysis instrument, X-ray diffractometer (XRD), and X-ray photoelectron spectrometer (XPS). The bi-layered disulfiram-loaded membranes showed the potent antibacterial activity in vitro against both Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). It was found that the bi-layered membranes had good biocompatibility with L929 cells. Thus, the obtained bi-layered disulfiram-loaded fiber membranes are suitable for wound dressing application.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 1359-1372 (14 pages)

Journal (Volume, Issue Number)

Applied Biochemistry and Biotechnology (Volume 194, Issue 3)

Publication milestones

  • Accepted/In press - 03/09/2021
  • Published - 29/10/2021

Publication status

Published - 29/10/2021

ISSN

0273-2289

External Publication IDs

  • handle.net: 10547/625377
  • Scopus: 85118321805

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