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AU-rich element RNA binding proteins: at the crossroads of post-transcriptional regulation and genome integrity

  • Ahmed Sidali
    ,
  • Varsha Teotia
    ,
  • Nadeen Shaikh Solaiman
    ,
  • Nahida Bashir
    ,
  • Kanagaraj Radhakrishnan
    ,
  • John J. Murphy
  • University of Westminster
Research Output: Contribution to journal Article Peer-review

Open access

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Genome integrity must be tightly preserved to ensure cellular survival and to deter the genesis of disease. Endogenous and exogenous stressors that impose threats to genomic stability through DNA damage are counteracted by a tightly regulated DNA damage response (DDR). RNA binding proteins (RBPs) are emerging as regulators and mediators of diverse biological processes. Specifically, RBPs that bind to adenine uridine (AU)-rich elements (AREs) in the 3′ untranslated region (UTR) of mRNAs (AU-RBPs) have emerged as key players in regulating the DDR and preserving genome integrity. Here we review eight established AU-RBPs (AUF1, HuR, KHSRP, TIA-1, TIAR, ZFP36, ZFP36L1, ZFP36L2) and their ability to maintain genome integrity through various interactions. We have reviewed canonical roles of AU-RBPs in regulating the fate of mRNA transcripts encoding DDR genes at multiple post-transcriptional levels. We have also attempted to shed light on non-canonical roles of AU-RBPs exploring their post-translational modifications (PTMs) and sub-cellular localization in response to genotoxic stresses by various factors involved in DDR and genome maintenance. Dysfunctional AU-RBPs have been increasingly found to be associated with many human cancers. Further understanding of the roles of AU-RBPS in maintaining genomic integrity may uncover novel therapeutic strategies for cancer. View Full-Text

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Article number

96

Journal (Volume, Issue Number)

International Journal of Molecular Sciences (Volume 23, Issue 1)

Publication milestones

  • Accepted/In press - 18/12/2021
  • Published - 22/12/2021

Publication status

Published - 22/12/2021

ISSN

1661-6596

External Publication IDs

  • handle.net: 10547/625288
  • Scopus: 85121429949
  • PubMed: 35008519

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