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Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase

Research Output: Contribution to journal Article Peer-review

Abstract

Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition.We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 422-424

Journal (Volume, Issue Number)

Placenta (Volume 35, Issue 6)

Publication milestones

  • Published - 12/04/2014

Publication status

Published - 12/04/2014

ISSN

0143-4004

External Publication IDs

  • handle.net: 10547/622564
  • Scopus: 84900442285

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