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Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer

  • Shaobo Zhou
    ,
  • Tao Zhang
    ,
  • Qingwang Li
    ,
  • Kun Li
    ,
  • Yurong Li
    ,
  • Jian Li
  • Jiamusi University
    ,
  • Harbin Medical University
    ,
  • Northwest Agriculture and Forestry University
    ,
  • Yanshan University
    ,
  • King's College London
Research Output: Contribution to journal Article Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

Saponin extracted from Patrinia villosa (Thunb.) Juss (SPVJ) is a Chinese medicine which is used widely by traditional medicine doctors. In this study, the antitumor effects and the possible mechanisms of SPVJ were investigated in mice bearing U14 cervical cancer. The results showed that SPVJ (50 mg/kg and 100 mg/kg) effectively reduced the weight of U14 cervical tumor (35.1% and 57.1%, respectively). Compared with the control group, SPVJ (100 mg/kg) significantly increased tumor cells in the G0/G1 phase (38.1% vs 68.5%), increased the number of cells in apoptosis (9.4% vs 28.9%) and G0/G1 phase and decreased the number of cells in S phase (41% vs 26.2%) and G2/M (20.9% vs 5.3%), inhibited proliferating cell nuclear antigen (PCNA) of tumor cell (80.6% vs 21.8%), decreased the expression of mutant p53 (66.4% vs 33.5%) and bcl-2 protein (78.2% vs 20.3%). The mechanism of the SPVJ antitumor effect might be associated with inhibition of tumor cells in G0/G1 phase, inducing apoptosis and inhibiting the expression of PCNA, mutant P53 and Bcl-2 protein.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 640-645

Journal (Volume, Issue Number)

Phytotherapy Research (Volume 22, Issue 5)

Publication milestones

  • Published - 29/04/2008

Publication status

Published - 29/04/2008

ISSN

0951-418X

External Publication IDs

  • handle.net: 10547/624610
  • Scopus: 44149123789

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