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Anti-degranulation response of herbal formula in RBL-2H3 cells

  • Jing Hu
    ,
  • Yujuan Chen
    ,
  • Jiajing Zhu
    ,
  • Mingyan Gao
    ,
  • Jiani Li
    ,
  • Zhengxun Song
  • Changchun University of Science and Technology
    ,
  • University of Warwick
Research Output: Contribution to journal Article Peer-review

Abstract

Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Journal (Volume, Issue Number)

Micron (Volume 130, Issue 102819)

Publication milestones

  • Accepted/In press - 27/12/2019
  • Published - 28/12/2019

Publication status

Published - 28/12/2019

ISSN

0968-4328

External Publication IDs

  • handle.net: 10547/624066
  • Scopus: 85077085157

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