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Androgens affect myogenesis in vitro and increase local IGF-1 expression.

  • Nicholas Sculthorpe
    ,
  • Andrew M. Solomon
    ,
  • Andrea C.M. Sinanan
    ,
  • Pierre- Marc G. Bouloux
    ,
  • Fergal Grace
    ,
  • Mark P. Lewis
  • University of Bedfordshire
    ,
  • University College London
    ,
  • Royal Free and University College Hospital Medical School
    ,
  • Kingston University
Research Output: Contribution to journal Article Peer-review

Abstract

The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 610-615

Journal (Volume, Issue Number)

Medicine and Science in Sports and Exercise (Volume 44, Issue 4)

Publication milestones

  • Published - 01/04/2012

Publication status

Published - 01/04/2012

ISSN

0195-9131

External Publication IDs

  • handle.net: 10547/223813
  • Scopus: 84858709584

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