Analysis of the mechanical properties of chromosomes in air and liquid by AFM

Bowei Wang
,
Fan Yang
,
Jianjun Dong
,
Jiani Li
,
Ying Wang
,
Kaige Qu

Changchun University of Science and Technology
,
Changli Nano Biotechnology

Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Open access

Abstract

Chromosomes contain all the genomic information thus making the study of chromosomes practical and significant. Herein, the morphologies of chromosomes prepared with different methods were monitored by atomic force microscopy (AFM). Moreover, the mechanical properties of chromosomes in air and liquid were investigated quantitatively through AFM-based force spectroscopy. The differences of chromosome morphologies and mechanical properties caused by sample preparations indicated that the chromosome characterization in liquid was more meaningful to reveal the physiological characteristics of chromosomes.

Publication Information

Output type

Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Original language

English

Pages from-to (Number of pages)

Pages 43-46 (4 pages)

Publication milestones

Accepted/In press - 01/07/2021
Published - 18/11/2021

Publication status

Published - 18/11/2021

Publisher

Institute of Electrical and Electronics Engineers Inc., United States

Publication series

Publication series name: 2021 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2021 - Proceedings