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An important role for RPRD1B in the heat shock response

  • Simona Cugusi
    ,
  • Prashanth Bajpe
    ,
  • Richard Mitter
    ,
  • Harshil Patel
    ,
  • Aengus Stewart
    ,
  • Jesper Q. Svejstrup
  • The Francis Crick Institute
    ,
  • University of Copenhagen
Research Output: Contribution to journal Article Peer-review

Open access

Abstract

During the heat shock response (HSR), heat shock factor (HSF1 in mammals) binds to target gene promoters, resulting in increased expression of heat shock proteins that help maintain protein homeostasis and ensure cell survival. Besides HSF1, only a relatively few transcription factors with a specific role in ensuring correctly regulated gene expression during the HSR have been described. Here, we use proteomic and genomic (CRISPR) screening to identify a role for RPRD1B in the response to heat shock. Indeed, cells depleted for RPRD1B are heat shock sensitive and show decreased expression of key heat shock proteins (HSPs). These results add to our understanding of the connection between basic gene expression mechanisms and the HSR.

Publication Information

Output type

Research Output: Contribution to journal Article Peer-review

Original language

English

Article number

e00173-22

Journal (Volume, Issue Number)

Molecular and Cellular Biology (Volume 42, Issue 10)

Publication milestones

  • Accepted/In press - 26/08/2022
  • Published - 20/10/2022

Publication status

Published - 20/10/2022

ISSN

0270-7306

External Publication IDs

  • handle.net: 10547/626252
  • Scopus: 85140416639
  • PubMed: 36121223

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