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A disulfiram-loaded fibers scaffold fabricated via electrospinning method

  • Chenchen Xie
    ,
  • Ran Ding
    ,
  • Xinyue Wang
    ,
  • Jin Yan
    ,
  • Ying Wang
    ,
  • Wenxiao Zhang
  • Changchun University of Science and Technology
Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Sustainable Development Goals

  • SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well

Abstract

In this study, we developed a disulfiram-loaded fibers scaffold via the electrospinning method for enhancing the stability of disulfiram and facilitating the appropriate distribution in tumor tissues. The drug release profile of the disulfiram-loaded fibers scaffold was examined by high-performance liquid chromatography. The results showed that both the initial burst release and the subsequent sustainable release of the drug were suitable for cancer treatments. The results of an MTT assay, which tested the therapeutic efficacy of electrospun fibers in vitro, showed that the DSF-PVDF fibers exhibited their anticancer activity due to the incorporation of DSF. It indicates that DSF is successfully incorporated into the electrospun fibers and the resultant electrospun fibers are highly promising for cancer treatments.

Publication Information

Output type

Research Output: Chapter in Book/Report/Conference proceeding Conference contribution Peer-review

Original language

English

Publication milestones

  • Published - 02/01/2020

Publication status

Published - 02/01/2020

Publisher

Institute of Electrical and Electronics Engineers Inc., United States

External Publication IDs

  • handle.net: 10547/624158
  • Scopus: 85078820723

Host publication title

2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)

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