TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Stefan D. Anker; Anna Baumgarten; Claudia Bang; Anika Tschirner; Anke Engelmann; Volker Adams; Stephan von Haehling; Wolfram Doehner; Reinhard Pregla; Markus S. Anker; Kinga Blecharz; Rudolf Meyer; Roland Hetzer; Thomas Thum; Jochen Springer

doi:10.1016/j.ijcard.2012.12.094

TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

Stefan D. Anker
, Anna Baumgarten
, Claudia Bang
, Anika Tschirner
, Anke Engelmann
, Volker Adams
, Stephan von Haehling
, Wolfram Doehner
, Reinhard Pregla
, Markus S. Anker
, Kinga Blecharz
, Rudolf Meyer
, Roland Hetzer
, Thomas Thum
, Jochen Springer

University of Bedfordshire

Charité – Universitätsmedizin Berlin
German Centre for Cardiovascular Research
Hannover Medical School
Fresenius AG
Deutsches Herzzentrum Berlin
IRCCS San Raffaele Pisana - Roma
University of East Anglia

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

Original language	English
Pages (from-to)	1447-1452
Journal	International Journal of Cardiology
Volume	168
Issue number	2
DOIs	https://doi.org/10.1016/j.ijcard.2012.12.094
Publication status	Published - 30 Sept 2013

Keywords

transcription factor

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10.1016/j.ijcard.2012.12.094

http://www.sciencedirect.com/science/article/pii/S0167527313000053

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Anker, S. D., Baumgarten, A., Bang, C., Tschirner, A., Engelmann, A., Adams, V., von Haehling, S., Doehner, W., Pregla, R., Anker, M. S., Blecharz, K., Meyer, R., Hetzer, R., Thum, T., & Springer, J. (2013). TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. International Journal of Cardiology, 168(2), 1447-1452. https://doi.org/10.1016/j.ijcard.2012.12.094

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title = "TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy",

abstract = "The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.",

keywords = "transcription factor",

author = "Anker, \{Stefan D.\} and Anna Baumgarten and Claudia Bang and Anika Tschirner and Anke Engelmann and Volker Adams and \{von Haehling\}, Stephan and Wolfram Doehner and Reinhard Pregla and Anker, \{Markus S.\} and Kinga Blecharz and Rudolf Meyer and Roland Hetzer and Thomas Thum and Jochen Springer",

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Anker, SD, Baumgarten, A, Bang, C, Tschirner, A, Engelmann, A, Adams, V, von Haehling, S, Doehner, W, Pregla, R, Anker, MS, Blecharz, K, Meyer, R, Hetzer, R, Thum, T & Springer, J 2013, 'TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy', International Journal of Cardiology, vol. 168, no. 2, pp. 1447-1452. https://doi.org/10.1016/j.ijcard.2012.12.094

TY - JOUR

T1 - TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

AU - Anker, Stefan D.

AU - Baumgarten, Anna

AU - Bang, Claudia

AU - Tschirner, Anika

AU - Engelmann, Anke

AU - Adams, Volker

AU - von Haehling, Stephan

AU - Doehner, Wolfram

AU - Pregla, Reinhard

AU - Anker, Markus S.

AU - Blecharz, Kinga

AU - Meyer, Rudolf

AU - Hetzer, Roland

AU - Thum, Thomas

AU - Springer, Jochen

PY - 2013/9/30

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N2 - The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

AB - The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.

KW - transcription factor

U2 - 10.1016/j.ijcard.2012.12.094

DO - 10.1016/j.ijcard.2012.12.094

M3 - Article

SN - 0167-5273

VL - 168

SP - 1447

EP - 1452

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -

TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy

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Keywords

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