Targeting the epigenome for treatment of cancer

E-J Geutjes; P K Bajpe; R Bernards

doi:10.1038/onc.2011.552

Targeting the epigenome for treatment of cancer

E-J Geutjes
, P K Bajpe
, R Bernards

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Cancer genome analyses have revealed that the enzymes involved in epigenetic gene regulation are frequently deregulated in cancer. Here we describe the enzymes that control the epigenetic state of the cell, how they are affected in cancer and how this knowledge can be exploited to treat cancer with a new arsenal of selective therapies.

Original language	English
Pages (from-to)	3827-3844
Journal	Oncogene
Volume	31
Issue number	34
DOIs	https://doi.org/10.1038/onc.2011.552
Publication status	Published - 5 Dec 2011

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title = "Targeting the epigenome for treatment of cancer",

abstract = "Cancer genome analyses have revealed that the enzymes involved in epigenetic gene regulation are frequently deregulated in cancer. Here we describe the enzymes that control the epigenetic state of the cell, how they are affected in cancer and how this knowledge can be exploited to treat cancer with a new arsenal of selective therapies. ",

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Targeting the epigenome for treatment of cancer

Abstract

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