Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

Stefan D. Anker; Sandra Palus; Stephan von Haehling; Valerie C. Flach; Anika Tschirner; Wolfram Doehner; Jochen Springer

doi:10.1016/j.ijcard.2013.04.150

Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

Stefan D. Anker
, Sandra Palus
, Stephan von Haehling
, Valerie C. Flach
, Anika Tschirner
, Wolfram Doehner
, Jochen Springer

University of Bedfordshire

Charité – Universitätsmedizin Berlin
German Centre for Cardiovascular Research
University of East Anglia

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.

Original language	English
Pages (from-to)	3412-3418
Journal	International Journal of Cardiology
Volume	168
Issue number	4
DOIs	https://doi.org/10.1016/j.ijcard.2013.04.150
Publication status	Published - 9 Oct 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer

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10.1016/j.ijcard.2013.04.150

http://www.sciencedirect.com/science/article/pii/S0167527313007997

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title = "Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia",

abstract = "Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.",

keywords = "cancer",

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AU - Anker, Stefan D.

AU - Palus, Sandra

AU - von Haehling, Stephan

AU - Flach, Valerie C.

AU - Tschirner, Anika

AU - Doehner, Wolfram

AU - Springer, Jochen

PY - 2013/10/9

Y1 - 2013/10/9

N2 - Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.

AB - Chronic inflammation is common in cancer cachexia (CC) and directly involved in the atrophy seen in this condition. Recently, several groups have described a form of cardiomyopathy in CC animal models. Hence, we investigated the effect of simvastatin with its known anti-inflammatory and cardioprotective effects in a rat model of CC.

KW - cancer

U2 - 10.1016/j.ijcard.2013.04.150

DO - 10.1016/j.ijcard.2013.04.150

M3 - Article

SN - 0167-5273

VL - 168

SP - 3412

EP - 3418

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 4

ER -

Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

Abstract

UN SDGs

Keywords

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