Abstract
The hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulintropic polypeptide (GIP) are secreted after a meal. Like other enteroendocrine hormones they help to orchestrate the bodies' response to the availability of newly absorbable nutrients and are noteworthy as they stimulate postprandial insulin secretion, underlying what is known as the incretin effect. GLP-1-mimetics are now widely used in the treatment of type 2 diabetes and advantages over older insulinotropic therapies include weight loss. An alternative treatment regime might be the recruitment of endogenous GLP-1, however, very little is known about the physiological control of enteroendocrine responses. This review focuses on the molecular mechanisms to detect nutrient arrival in the gut that have been implicated within the incretin secreting cells.
| Original language | English |
|---|---|
| Pages (from-to) | 387-393 |
| Number of pages | 7 |
| Journal | Physiology and Behavior |
| Volume | 106 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 13 Dec 2011 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Glucagon-like peptide-1 (GLP-1)
- Glucose-dependent insulinotropic polypeptide (GIP)
- Intestinal K-cells
- Intestinal L-cells
- Nutrient sensing
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience
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